Abstract
Background and aim: Ceftriaxone is a third generation Cephalosporin and is often used to treat infections of the upper gastrointestinal tract and urinary tract infections. Due to some reported side effects of these drugs, such as urinary stone formation which may be related to hypercalciuria, this study aimed to determine the effect of ceftriaxone in the treatment of urinary tract infection with urinary stone formation.
Methods: This cross-sectional study was carried out on 120 children from the age of 2 months to 14 years with febrile infections admitted to the Children's Hospital of Bandar Abbas in 2016. Patients were randomly allocated to two groups: The first group received a dose of ceftriaxone 100-50 mg/kg every 12 hours (depending on severity) and in the second group, ampicillin 50 mg/kg every 6 hours and cefotaxime 50 mg/kg every 8 hours were administered. For evaluation of hypercalciuria calcium to creatinine ratio (ca/cr) in random urine was used. Hypercalciuria was defined as Ca/Cr>0.6 in infants<1 years old and Ca/Cr>0.2 in infants>1 year old. Data was analyzed by IBM-SPSS version 21 through descriptive statistics, Chi-square, Fisher's exact test, independent samples t-test, and paired samples t-test. P-value less than 0.05 was considered significant.
Results: A total of 120 children were enrolled in the study (78 in the ceftriaxone group vs. 42 in the ampicillin and ceftriaxone group). Both groups were similar in terms of age, gender, creatinine ratio and pre-treatment Ca/Cr ratio, but the difference between the groups was compared after treatment (0.339±0.204 in the ceftriaxone group and 0.236±0.159 in ampicillin and cefotaxime group) (p=0.005). The prevalence of hypercalciuria in the group receiving ceftriaxone, 15 (19.2%) and in the group receiving Ampicillin 2 (4.8%) (p<0.03).
Conclusion: According to the information obtained from this study, we found out that ceftriaxone can increase the risk of hypercalciuria. Further studies with different populations could help to raise awareness of this issue.
 
Keywords: Ceftriaxone, Cefotaxime, Hypercalciuria

 

» HTML Fulltext    » PDF Fulltext    » doi: 10.19082/7450
KD VIII Elite HighFASHION NEWS

Current Issue

Volume 12, Issue 3, July-September 2020

 


 

The worldwide spread of COVID-19 as an emerging, rapidly evolving situation, and the dramatic need of urgent medicine or vaccine, has rapidly brought new hypotheses for pathophysiology and potential medicinal agents to the fore. It is crucial that the research community provide a way to publish this research in a timely manner.

To contribute to this important public health discussion, the Electronic Physician Journal is excited to announce a fast-track procedure to help researchers publish their articles on COVID-19 related subjects that fall under the broad definition of public health, internal medicine, and pharmacology. We are especially welcome to all hypotheses about the pathological basis of the COVID-19 infection and the possible characteristics of potential medicine and vaccine. Submit your manuscript here


 

The 6th World Conference on Research Integrity (WCRI) is to be held on June 2-5, 2019 in Hong Kong.

The WCRI is the largest and most significant international conference on research integrity. Since the first conference in Lisbon in 2007, it has given researchers, teachers, funding agencies, government officials, journal editors, senior administrators, and research students opportunities to share experiences and to discuss and promote integrity in research. Read more:


 

TDR Clinical Research and Development Fellowships

Call for applications

Deadline for submission: 7 March 2019, 16:00 (GMT)

TDR provides fellowships for early- to mid-career researchers and clinical trial staff (e.g. clinicians, pharmacists, medical statisticians, data managers, other health researchers) in low- and middle-income countries (LMICs) to learn how to conduct clinical trials. Read more:


Meta-Analysis Workshops in New York, USA, and London, UK, in April and May 2019

Don't miss this exceptional opportunity to learn how to perform and report a Meta-analysis correctly. Two Meta-analysis workshops are organized in April and May 2019 by Dr. Michael Borenstein in New York, USA (April 08-10, 2019) and London, UK (May 27-29).

About the Instructor

Dr. Michael Borenstein, one of the authors of Introduction to Meta-Analysis, is widely recognized for his ability to make statistical concepts accessible to researchers as well as to statisticians. He has lectured widely on meta-analysis, including at the NIH, CDC, and FDA. Read more: