Abstract
Background: Preterm neonates have a higher tendency in developing infections and their umbilical cord serves as a good environment for bacterial growth. 
Objective: The aim of this study was to compare the topical effects of breast milk, chlorhexidine and dry cord care methods on bacterial colonization of preterm neonates’ umbilical cord in the Neonatal Intensive Care Unit (NICU)
Methods: The trial was one-centered, single-blind, and in phase 2 of clinical trials from Vali-e-Asr Educational Hospital, Birjand, Iran from January to June 2017. A sample of 75 preterm infants were recruited by convenience sampling method and assigned into one of the three groups of drying, chlorhexidine, and milk by using a table of random numbers (n=25 per group). Bacterial colonization and its density were assessed in all groups during the first 12 to 24 hours of admission, and again after 72 hours. A total of 25 subjects were entered in each group and the data were analyzed by Chi-square tests (Fisher's exact test), Kruskal–Wallis analysis, Wilcoxon test, McNemar's test, and ANOVA.
Results: The bacteria colonized in the newborns of groups I, II, and III before and after intervention were 64% and 36% (p=0.03), 52 and 20% (p=0.008) and 64 and 32 (p=0.02) respectively. After the intervention, colonized bacteria were significantly decreased in all three groups.
Conclusion: Based on the results of this study, all three methods of drying approach, use of chlorhexidine, as well as breast milk were effective in controlling bacterial colonization in the umbilical cord of preterm neonates. Although there were no significant differences between the three groups, ultimately the use of these methods could be effective in reducing the need for antibiotics.
Trial registration: Prior to the study, the protocol of study was registered at Iran's Clinical Trials Registry (http://www.irct.ir) (Registration ID: IRCT2017090517756N27).  
Funding: The present study was funded fully by Birjand University of Medical Sciences (grant number: 455078).
 
Keywords: Infant, Premature, Umbilical cord, Milk, Human, Chlorhexidine

 

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Volume 12, issue 2, April-June 2020

 


 

The worldwide spread of COVID-19 as an emerging, rapidly evolving situation, and the dramatic need of urgent medicine or vaccine, has rapidly brought new hypotheses for pathophysiology and potential medicinal agents to the fore. It is crucial that the research community provide a way to publish this research in a timely manner.

To contribute to this important public health discussion, the Electronic Physician Journal is excited to announce a fast-track procedure to help researchers publish their articles on COVID-19 related subjects that fall under the broad definition of public health, internal medicine, and pharmacology. We are especially welcome to all hypotheses about the pathological basis of the COVID-19 infection and the possible characteristics of potential medicine and vaccine. Submit your manuscript here


 

The 6th World Conference on Research Integrity (WCRI) is to be held on June 2-5, 2019 in Hong Kong.

The WCRI is the largest and most significant international conference on research integrity. Since the first conference in Lisbon in 2007, it has given researchers, teachers, funding agencies, government officials, journal editors, senior administrators, and research students opportunities to share experiences and to discuss and promote integrity in research. Read more:


 

TDR Clinical Research and Development Fellowships

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Deadline for submission: 7 March 2019, 16:00 (GMT)

TDR provides fellowships for early- to mid-career researchers and clinical trial staff (e.g. clinicians, pharmacists, medical statisticians, data managers, other health researchers) in low- and middle-income countries (LMICs) to learn how to conduct clinical trials. Read more:


Meta-Analysis Workshops in New York, USA, and London, UK, in April and May 2019

Don't miss this exceptional opportunity to learn how to perform and report a Meta-analysis correctly. Two Meta-analysis workshops are organized in April and May 2019 by Dr. Michael Borenstein in New York, USA (April 08-10, 2019) and London, UK (May 27-29).

About the Instructor

Dr. Michael Borenstein, one of the authors of Introduction to Meta-Analysis, is widely recognized for his ability to make statistical concepts accessible to researchers as well as to statisticians. He has lectured widely on meta-analysis, including at the NIH, CDC, and FDA. Read more: