Abstract
Background: Chronic periodontitis is a common public health concern characterized by progressive gingival inflammation. 
Objective: This study assessed the clinical and laboratory effect of diacerein as adjunctive therapy to scaling and root planing (SRP) in the therapeutic management of moderate chronic periodontitis. 
Methods: This double-blind randomized controlled trial was conducted on thirty patients suffering from moderate chronic periodontitis at the dental clinic in the Faculty of Dentistry (University of Mansoura, Egypt) between March-October 2018. The participants were randomly allocated into two groups of fifteen subjects each. The control and study group received SRP and diacerein was administered to the study group in the form of a gel-formula applied to the periodontal pocket for 6 weeks. The clinical periodontal parameters assessed pre- and post-treatment were plaque index (PI), gingival index (GI), probing depth, and clinical attachment level (CAL). Samples of gingival crevicular fluid (GCF) were also collected at baseline and six weeks after the initiation of the treatment for IL-1ß assessment using ELISA. Clinical parameters collected were compared between and after treatment by descriptive and inferential statistical analysis using IBM© SPSS© Statistics version 20.
Results: Age and gender were not significantly different between the two groups. There was a significant decrease in the median values of clinical indices post-treatment compared to pre-treatment in the study group (test significance=23.07; p<0.001). Interestingly, there was a significant decrease in IL-β1 after treatment in both groups, with a more significant decrease in the study group compared to the control group (p=0.0001). 
Conclusion: Diacerein is an alternative and promising therapeutic option for the management and control of chronic periodontitis. 
Clinical Trial Registration: The trial has been registered at http://www.clinicaltrials.in.th with registration ID: TCTR20190930001.
Funding: No funds or financial support, governmental or non-governmental, was received
 
Keywords: Periodontitis; Chronic periodontitis; Scaling and root planning; Diacerein; IL-β1

 

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Volume 12, Issue 4, October-December 2020

 


 

The worldwide spread of COVID-19 as an emerging, rapidly evolving situation, and the dramatic need of urgent medicine or vaccine, has rapidly brought new hypotheses for pathophysiology and potential medicinal agents to the fore. It is crucial that the research community provide a way to publish this research in a timely manner.

To contribute to this important public health discussion, the Electronic Physician Journal is excited to announce a fast-track procedure to help researchers publish their articles on COVID-19 related subjects that fall under the broad definition of public health, internal medicine, and pharmacology. We are especially welcome to all hypotheses about the pathological basis of the COVID-19 infection and the possible characteristics of potential medicine and vaccine. Submit your manuscript here


 

The 6th World Conference on Research Integrity (WCRI) is to be held on June 2-5, 2019 in Hong Kong.

The WCRI is the largest and most significant international conference on research integrity. Since the first conference in Lisbon in 2007, it has given researchers, teachers, funding agencies, government officials, journal editors, senior administrators, and research students opportunities to share experiences and to discuss and promote integrity in research. Read more:


 

TDR Clinical Research and Development Fellowships

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Deadline for submission: 7 March 2019, 16:00 (GMT)

TDR provides fellowships for early- to mid-career researchers and clinical trial staff (e.g. clinicians, pharmacists, medical statisticians, data managers, other health researchers) in low- and middle-income countries (LMICs) to learn how to conduct clinical trials. Read more:


Meta-Analysis Workshops in New York, USA, and London, UK, in April and May 2019

Don't miss this exceptional opportunity to learn how to perform and report a Meta-analysis correctly. Two Meta-analysis workshops are organized in April and May 2019 by Dr. Michael Borenstein in New York, USA (April 08-10, 2019) and London, UK (May 27-29).

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Dr. Michael Borenstein, one of the authors of Introduction to Meta-Analysis, is widely recognized for his ability to make statistical concepts accessible to researchers as well as to statisticians. He has lectured widely on meta-analysis, including at the NIH, CDC, and FDA. Read more: