Background: Oral health preservation is of major importance in patients undergoing periodontal surgery. Tooth brushing is a competency that is challenging to perform. Therefore, materials with biochemical properties that can control the tooth plaque biofilm are used.
Objective: The purpose of the study was to determine the clinical outcome of alcohol-free Chlorhexidine (AFCHX) 0.12% oral rinse in comparison with 0.05% Cetylpyridinium chloride (CPC) non-alcoholic mouthwash in outpatients with periodontitis.
Methods: Patients with periodontal diseases attending the Department of Periodontology, Dental School of the Islamic Azad University of Medical Sciences, Tehran, Iran received a double-blind randomized controlled trial. In this study, a total of 38 patients with gingivitis and pocket depth ≤4 mm were randomly allocated into two equal study groups and followed up within 90 days: Group A (performed mouth rising twice a day with the liquid including 10 ml of the 0.05% CPC without ethanol), Group B (performed mouth rising twice daily with 10 ml of the alcohol-free 0.012% chlorhexidine solution). Furthermore, periodontal parameters and Stain Index (SI) were obtained at baseline and for both groups one month later. ANOVA was used to analyze the data. Statistical significance was defined as p-value <0.05.  
Results: Full-mouth plaque index (PI) was non-significantly different in the two groups, and the decline was 35% for the CPC group and 44% for the individual AFCHX group. Moreover, reductions in BOP were statistically significant for the CHX group after the 12th week (p=0.0001). Additionally, the PD drop within 30 days was statistically significant (1.92±0.30) AFCHX group and (2.30±0.36) CPC group (p=0.002). Meanwhile, CPC and AFCHX plan of teeth were also compared, and greater rates of staining were observed in AFCHX areas of teeth at days 7 to four weeks.
Conclusion: The findings indicated that the application of a therapeutic CPC mouth rinse, twice daily aids control plaque as well as gingivitis, and periodontitis surpassing traditional plaque control, although not as much as AFCHX mouthwash.
Trial registration: The study was registered under Identifier No. NCT02756377 at ClinicalTrials.gov.
Funding: This study was entirely sponsored by researchers and did not receive a specific grant from any funding agency.
Keywords: Cetylpyridinium, Chlorhexidine, Periodontal disease


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