Written by Asad Setayesh, Farhad Ghahramani, Saeed Hosseini Teshnize, Hamidreza Mahboobi, Keramat Allah Jahanshahi, Elizabeth Cottrell
Parent Category: Browse issues of Electronic Physician by year and volume
Category: Year 2010, Volume 2
Background: Treatment of vomiting in acute gastroenteritis can increase the rate of successful oral rehydration therapy (ORT) and lower the need for intravenous fluid administration. The aim of this study was to investigate the role of ondansetron in decreasing vomiting and duration of hospitalization in 6 month to 14 year old children.
Methods: In 2010, a double blind randomized controlled trial was carried out based on 100 children between six months and 14 years old with acute gastroenteritis and vomiting. Each child satisfied the inclusion criteria and agreed to participate in the study after receiving a complete explanation about the study. Participants were randomly divided into two groups to either receive intravenous ondansetron (single dose of 0.15mg/kg) or an intravenous placebo (5% dextrose water). The duration of hospitalization and number of vomiting episodes were compared between the two groups 4 hours after treatment. Data were analyzed using SPSS16 software.
Results: Duration of hospitalization was 38.30±18.62 hours in those receiving ondansetron and 45.10±25.79 hours in the control group. There was no statistically significant difference between the two groups (P=0.352). The number of vomiting episodes was 0.06±0.23 in the ondansetron group and 0.58±0.90 in the control group. This difference is statistically significant (P=0.000). No adverse effects were seen in either group relating to the drug.
Conclusions: This study demonstrated that intravenous ondansetron can effectively reduce the frequency of vomiting associated with acute gastroenteritis. We recommend administration of ondansetron for management of children with acute gastroenteritis but further studies with a larger sample size would be beneficial.
Key words: Ondansetron, acute gastroenteritis; vomiting; oral rehydration therapy (ORT)
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The most recent editorial (June 2021)
Ethics of Publishing Case Reports: Do We Need Ethics Approval and Patient Consent?
An editorial by Dr. Mehrdad Jalalian
The worldwide spread of COVID-19 as an emerging, rapidly evolving situation, and the dramatic need of urgent medicine or vaccine, has rapidly brought new hypotheses for pathophysiology and potential medicinal agents to the fore. It is crucial that the research community provide a way to publish this research in a timely manner.
To contribute to this important public health discussion, the Electronic Physician Journal is excited to announce a fast-track procedure to help researchers publish their articles on COVID-19 related subjects that fall under the broad definition of public health, internal medicine, and pharmacology. We are especially welcome to all hypotheses about the pathological basis of the COVID-19 infection and the possible characteristics of potential medicine and vaccine. Submit your manuscript here
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The 6th World Conference on Research Integrity (WCRI) is to be held on June 2-5, 2019 in Hong Kong.
The WCRI is the largest and most significant international conference on research integrity. Since the first conference in Lisbon in 2007, it has given researchers, teachers, funding agencies, government officials, journal editors, senior administrators, and research students opportunities to share experiences and to discuss and promote integrity in research. Read more:
TDR Clinical Research and Development Fellowships
Call for applications
Deadline for submission: 7 March 2019, 16:00 (GMT)
TDR provides fellowships for early- to mid-career researchers and clinical trial staff (e.g. clinicians, pharmacists, medical statisticians, data managers, other health researchers) in low- and middle-income countries (LMICs) to learn how to conduct clinical trials. Read more:
Meta-Analysis Workshops in New York, USA, and London, UK, in April and May 2019
Don't miss this exceptional opportunity to learn how to perform and report a Meta-analysis correctly. Two Meta-analysis workshops are organized in April and May 2019 by Dr. Michael Borenstein in New York, USA (April 08-10, 2019) and London, UK (May 27-29).
About the Instructor
Dr. Michael Borenstein, one of the authors of Introduction to Meta-Analysis, is widely recognized for his ability to make statistical concepts accessible to researchers as well as to statisticians. He has lectured widely on meta-analysis, including at the NIH, CDC, and FDA. Read more: